Labbé SM, Mouchiroud M, Caron A, Secco B, Freinkman E, Lamoureux G, Gélinas Y, Lecomte R, Bossé Y, Chimin P, Festuccia WT, Richard D, Laplante M (2016) mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold. Sci Rep. 2016 Nov 23;6:37223. doi: 10.1038/srep37223.

    Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG. (2016) Environment dictates dependence on mitochondrial Complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin. Cell Metab pii: S1550-4131(16)30484-3. PubMed

    Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG. (2016) Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353(6304):1161-5. PubMed

    Chen W.W., Freinkman E., Wang T., Birsoy K., Sabatini D.M. (2016) Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166:1324-1337.

    Knudsen E.K., Balaji U., Freinkman E., McCue P., Witkiewicz A.K. (2016) Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget, PubMed.

    Woznica A., Cantley A.M., Beemelmanns C., Freinkman E., Clardy J., King N. (2016) Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Nat Acad Sci 113:7894-9. PubMed

    Smulan L.J., Ding W., Freinkman E., Gujja S., Edwards Y.J., Walker A.K. (2016) Cholesterol-independent SREBP-1 maturation is linked to ARF1 inactivation. Cell Rep 16:9-18. PubMed

    Pacold M.E., Brimacombe K.R., Chan S.H., Rohde J.M., Lewis C.A., Swier L.J., Possemato R., Chen W.W., Sullivan L.B., Fiske B.P., Cho S., Freinkman, E, Birsoy K., Abu-Remaileh M., Shaul Y.D., Liu C.M., Zhou M., Koh M., Chung H., Davidson S.M., Luengo A., Wang A.Q., Xu X., Yasgar A., Liu L., Rai G., Westover K.D., Vander Heiden M.G., Shen M., Gray N.S., Boxer M.B., Sabatini D.M. (2016) A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol 12:452-458. PubMed

    Franco J., Balaji U., Freinkman E., Witkiewicz A.K., Knudsen S. (2016) Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities. Cell Reports 14:979-990. PubMed

    Tafesse F.G., Rashidfarrokhi A., Schmidt F.I., Freinkman E., Dougan S., Dougan M., Esteban A., Maruyama T., Strijbis K., Ploegh H. (2015) Disruption of sphingolipid biosynthesis blocks phagocytosis of Candida albicans. PLoS Pathogens, published 02 Oct. 2015; DOI: 10.1371/journal.ppat.1005188. Full text online

    Birsoy K., Wang T., Chen W.W., Freinkman E., Abu-Remaileh M., Sabatini D.M. (2015) An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 162(1):540-551. PubMed.

    Sullivan L.B., Gui D.Y., Hosios A.M., Bush L.N., Freinkman E., Vander Heiden M.G. (2015) Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 162(1):552-563. PubMed.

    Kim D., Fiske B.P., Birsoy K., Freinkman E., Kami K., Possemato R.L., Chudnovsky Y., Pacold M.E., Chen W.W., Cantor J.R., Shelton L.M., Gui D.Y., Kwon M., Ramkissoon S.H., Ligon K.L., Kang S.W., Snuderl M., Vander Heiden M.G., Sabatini D.M. (2015) SHMT2 drives glioma cell survival in ischemia but imposes a dependence on glycine clearance. Nature 520(7547):363-7. PubMed.

    Shaul Y.D., Freinkman E., Comb W.C., Cantor J.R., Tam W.L., Thiru P., Kim D., Pacold M.E., Chen W.W., Bierie B., Possemato R., Weinberg R.A., Yaffe M.B., Sabatini D.M. (2014) DPYD is a key component of a metabolic program required for the epithelial-mesenchymal transition. Cell 158(5):1094-1109. PubMed.

    Schwartz S., Mumbach M.R., Jovanovic M., Wang T., Maciag K., Bushkin G.G., Mertins P., Ter-Ovanesyan D., Habib N., Cacchiarelli D., Sanjana N.E., Freinkman E., Pacold M.E., Satija R., Mikkelsen T.S., Zhang F., Carr S.A., Lander E.S., Regev A. (2014) Perturbation of m6A writers reveals two distinct classes of RNA methylation at internal and 5’ sites. Cell Rep 8(1):284-96. PubMed.

    Lee C.C., Freinkman E., Sabatini D.M., Ploegh H.L. (2014) The protein synthesis inhibitor blasticidin S enters mammalian cells via Leucine-Rich Repeat-Containing Protein 8D. J Biol Chem 289(24):17124-17131. PubMed.